There are three plays by this name.

Handy Andy a stage play by H.W. Montgomery ()

An stage adaptation by H.W. Montgomery (fl. 1860s) of the novel Handy Andy: A Tale of Irish Life by Samuel Lover (1797-1868), first published in 1842. The play was performed at Wallack's Theatre, New York in 1862.

Performances in South Africa

1878: Performed by the Colonial Amateur Minstrels and Sutton Vane in the Mutual Hall, Cape Town on 8 August, with Our Carpet Bag (Anon.)

Sources

Frederick Wilse Bateson. 1940. The Cambridge Bibliography of English Literature. 1. 600 - 1660, Volume 2 CUP Archive[1]

Handy Andy - a 1934 film

A filmed version of the stage play Merry Andrew by Lewis Beach (), produced by Fox and released in 1934, the film featured comedian Will Rogers in the lead. Directed by David Butler, with music and lyrics by Richard Whiting and William Conselman.

Sources

https://www.nytimes.com/1934/08/04/archives/will-rogers-peggy-wood-and-mary-carlisle-in-a-film-version-of-the.html

https://www.imdb.com/title/tt0025217/fullcredits/?ref_=tt_ov_st_sm

Handy Andy by Mike Mecek ()

Action comedy for young actors first developed and performed in 2016-7, with readings by PEACE Productions and the American Theatre Group of Strasbourg (2016) and TUFC (Théâtre Universitaire de Franche Comté), 2017. Performed University, TUFC (Théâtre Universitaire de Franche-Comté) and Le Petit Théâtre de la Bouloie (2018)